Alain Hovnanian Selected Research

Darier Disease (Darier's Disease)

7/2014	SERCA2 dysfunction in Darier disease causes endoplasmic reticulum stress and impaired cell-to-cell adhesion strength: rescue by Miglustat.
5/2011	Darier disease : a disease model of impaired calcium homeostasis in the skin.
10/2006	Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease.
2/2006	Activity of the hSPCA1 Golgi Ca2+ pump is essential for Ca2+-mediated Ca2+ response and cell viability in Darier disease.
10/2004	Darier's disease: from dyskeratosis to endoplasmic reticulum calcium ATPase deficiency.
12/2003	Impaired trafficking of the desmoplakins in cultured Darier's disease keratinocytes.
11/2003	Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses.
9/2003	Mutations in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase isoform cause Darier's disease.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Alain Hovnanian Research Topics

Disease

31	Netherton Syndrome 01/2022 - 02/2002
16	Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa) 11/2021 - 09/2002
9	Inflammation (Inflammations) 10/2020 - 08/2007
8	Skin Diseases (Skin Disease) 01/2020 - 09/2007
8	Darier Disease (Darier's Disease) 07/2014 - 09/2003
7	Genetic Skin Diseases 12/2016 - 10/2004
6	Atopic Dermatitis (Atopic Eczema) 01/2020 - 05/2009
4	Epidermolysis Bullosa Simplex (Epidermolysis Bullosa Herpetiformis Dowling Meara) 01/2022 - 04/2006
4	Blister (Bulla) 01/2022 - 07/2003
4	Hidradenitis Suppurativa 10/2020 - 11/2015
4	Hypersensitivity (Allergy) 09/2014 - 02/2008
4	Benign Familial Pemphigus (Hailey Hailey Disease) 02/2006 - 02/2002
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 04/2010
2	Epidermolysis Bullosa Acquisita (Acquired Epidermolysis Bullosa) 03/2021 - 06/2016
2	Erythema 01/2020 - 03/2010
2	Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris) 01/2020 - 01/2019
2	Neoplasms (Cancer) 01/2019 - 01/2018
2	Epidermolytic Hyperkeratosis (Bullous Congenital Ichthyosiform Erythroderma) 06/2017 - 10/2010
2	Exfoliative Dermatitis (Erythroderma) 03/2014 - 02/2002
2	Stevens-Johnson Syndrome (Lyell's Syndrome) 07/2011 - 02/2008
2	Infections 09/2007 - 10/2006
2	Lamellar Ichthyosis (Harlequin Ichthyosis) 03/2007 - 07/2005
1	Bullous Pemphigoid (Pemphigoid) 03/2021
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 07/2020
1	Job Syndrome (Hyper-IgE Syndrome) 01/2020
1	Pain (Aches) 10/2019
1	Epidermolysis Bullosa 01/2019
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2019
1	Squamous Cell Carcinoma of Head and Neck 01/2018
1	Virus Diseases (Viral Diseases) 10/2017
1	Wounds and Injuries (Trauma) 01/2016
1	Acne Vulgaris 11/2015
1	Pyoderma Gangrenosum 11/2015
1	Erythrokeratodermia Variabilis 06/2015
1	Necrosis 02/2013
1	Naegeli syndrome 10/2011
1	Drug-Related Side Effects and Adverse Reactions 07/2011
1	Carcinogenesis 12/2010

Drug/Important Bio-Agent (IBA)

16	Peptide Hydrolases (Proteases)FDA Link 01/2022 - 01/2005
15	Collagen Type VIIIBA 11/2021 - 03/2006
13	Kallikreins (Kallikrein)IBA 01/2022 - 05/2009
11	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 01/2021 - 10/2003
10	Proteins (Proteins, Gene)FDA Link 07/2020 - 02/2002
8	Serine Peptidase Inhibitor Kazal-Type 5IBA 01/2021 - 02/2002
6	Protease Inhibitors (Protease Inhibitor)IBA 01/2022 - 07/2006
6	Adenosine Triphosphatases (ATPase)IBA 02/2006 - 02/2002
5	Serine Proteases (Serine Protease)IBA 01/2022 - 08/2007
4	Pharmaceutical PreparationsIBA 01/2022 - 07/2011
4	Keratins (Keratin)IBA 06/2017 - 12/2003
3	LipidsIBA 05/2014 - 07/2005
3	Thymic Stromal LymphopoietinIBA 03/2014 - 05/2009
3	CalciumIBA 05/2011 - 12/2003
3	Calcium-Transporting ATPases (Ca2+ ATPase)IBA 10/2006 - 09/2003
3	Protein Isoforms (Isoforms)IBA 02/2006 - 09/2003
2	AutoantibodiesIBA 03/2021 - 06/2016
2	Immunoglobulin E (IgE)IBA 10/2014 - 02/2002
2	Filaggrin ProteinsIBA 03/2014 - 03/2010
2	TrypsinIBA 01/2013 - 07/2006
2	Keratin-14 (Keratin 14)IBA 10/2011 - 04/2006
2	HLA-B Antigens (HLA-B)IBA 07/2011 - 02/2008
2	pancreatic elastase IIIBA 08/2010 - 03/2010
2	Nevirapine (Viramune)FDA Link 02/2008 - 02/2008
2	CathelicidinsIBA 08/2007 - 10/2006
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2022
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2022
1	ixekizumabIBA 05/2021
1	Tryptophan (L-Tryptophan)FDA Link 10/2020
1	IndolesIBA 10/2020
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 10/2020
1	16S Ribosomal RNAIBA 01/2020
1	secukinumabIBA 01/2020
1	dupilumabIBA 01/2020
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2020
1	staphylococcal delta toxinIBA 01/2020
1	Sirolimus (Rapamycin)FDA Link 01/2020
1	Keratin-5 (Keratin 5)IBA 01/2019
1	ON 01910IBA 01/2019
1	diacereinIBA 01/2018
1	APOBEC DeaminasesIBA 01/2018
1	RNA (Ribonucleic Acid)IBA 01/2018
1	VaccinesIBA 10/2017
1	Antiviral Agents (Antivirals)IBA 10/2017
1	Biological ProductsIBA 01/2017
1	Antisense OligoribonucleotidesIBA 12/2016
1	Ertapenem (Invanz)FDA Link 02/2016
1	Anti-Bacterial Agents (Antibiotics)IBA 11/2015
1	ConnexinsIBA 06/2015
1	matriptaseIBA 01/2015
1	AllergensIBA 10/2014
1	miglustat (Zavesca)FDA Link 07/2014
1	EnzymesIBA 06/2014
1	1,2,4-triazoleIBA 08/2013
1	CytokinesIBA 02/2013
1	Chemokine CCL17IBA 02/2013
1	Chemokine CCL22IBA 02/2013
1	LigandsIBA 01/2013
1	Small Interfering RNA (siRNA)IBA 06/2012

Therapy/Procedure

10	Therapeutics 01/2022 - 09/2002
1	Subcutaneous Injections 12/2016
1	Intravenous Injections 07/2013